Table 4a.

Hazard ratios for melanoma for some variables (BRCA1 subjects)

Variables	Controls/ cases	Univariate HR (95%CI) P-value	Multivariate HR (95%CI) P-value
Age at baseline in years
<=40	1237/5	1	1
41–50	1099/10	2.40 (0.82, 7.03) 0.11	1.90(0.63, 5.73) 0.26
>=51	1264/8	1.80 (0.59, 5.51) 0.30	1.47(0.46, 4.73) 0.52
Breast cancer at baseline
No	1969/10	1	1
Yes	1629/13	1.72 (0.76, 3.93) 0.20	1.61 (0.66, 3.92) 0.30
Hormone replacement therapy
No	2300/11	1	1
Yes	1299/12	1.65 (0.73, 3.74) 0.23	1.62 (0.68, 3.85) 0.28
Melanoma at baseline
No	3481/20	1	1
Yes	28/2	11.9 (2.78, 50.9) 0.0008	9.45 (2.16, 41.3) 0.003
Family history of melanoma
No	1406/13	1	1
Yes, melanoma	9/0	0	0
Country
Canada	1610/7	1	1
USA	1990/16	2.41 (1.00, 5.93) 0.05	1.26 (0.35–4.58) 0.73