Table 1.
Comparison Between Average Performance Metrics With Control-IQ for Each Study Case.
| Overall | Lispro | URLi | URLi ↑ MB |
URLi ↑ BR |
URLi ↑ MB, BR | Lispro ↑ MB, BR |
|---|---|---|---|---|---|---|
| Average glucose (mg/dL) | 157.0 ± 8.6 | 156.1 ± 8.3 | 154.8 ± 8.5 | 153.2 ± 8.3 | 152.0 ± 8.5 | 146.2 ± 8.8 |
| Coefficient of variation (%) | 31.6 ± 6.4 | 28.4 ± 6.0 | 28.5 ± 6.0 | 28.6 ± 6.0 | 28.7 ± 5.9 | 32.3 ± 6.1 |
| % time <54 mg/dL | 0.5 ± 0.6 | 0.2 ± 0.4 | 0.3 ± 0.4 | 0.3 ± 0.4 | 0.3 ± 0.5 | 0.9 ± 0.9 |
| % time <70 mg/dL | 1.8 ± 1.5 | 1.0 ± 1.0 | 1.1 ± 1.1 | 1.1 ± 1.2 | 1.2 ± 1.2 | 2.9 ± 2.0 |
| % time in 70 to 140 mg/dL | 41.9 ± 6.9 | 41.2 ± 7.6 | 42.4 ± 7.6 | 44.0 ± 7.4 | 45.1 ± 7.5 | 50.2 ± 7.9 |
| % time in 70 to 180 mg/dL | 70.2 ± 8.0 | 72.9 ± 7.9 | 73.7 ± 8.0 | 74.4 ± 8.2 | 75.2 ± 8.2 | 75.2 ± 8.6 |
| % time >180 mg/dL | 28.0 ± 7.2 | 26.1 ± 7.5 | 25.2 ± 7.6 | 24.4 ± 7.7 | 23.6 ± 7.8 | 22.0 ± 7.5 |
| % time >250 mg/dL | 5.9 ± 5.5 | 4.1 ± 4.8 | 3.9 ± 4.7 | 3.6 ± 4.6 | 3.4 ± 4.4 | 3.7 ± 4.3 |
| Total daily insulin (U) | 46.0 ± 14.9 | 45.5 ± 14.7 | 45.9 ± 14.9 | 46.2 ± 15.0 | 46.5 ± 15.1 | 48.9 ± 15.9 |
| Total daily basal (U) | 23.3 ± 7.3 | 23.6 ± 7.4 | 23.5 ± 7.3 | 24.8 ± 7.7 | 24.6 ± 7.6 | 25.6 ± 8.0 |
| Total daily meal bolus (U) | 16.0 ± 6.4 | 16.0 ± 6.3 | 16.9 ± 6.7 | 15.9 ± 6.4 | 16.8 ± 6.7 | 18.4 ± 7.4 |
| Total daily corrections (U) | 6.8 ± 3.7 | 5.8 ± 3.4 | 5.5 ± 3.3 | 5.5 ± 3.3 | 5.2 ± 3.2 | 4.9 ± 3.2 |
| Total # hypo-treatments | 11.0 ± 10.0 | 6.0 ± 6.0 | 7.0 ± 7.0 | 7.0 ± 7.0 | 8.0 ± 7.0 | 18.0 ± 13.0 |
| 6 am to 12 am | Lispro | URLi | URLi ↑ MB |
URLi ↑ BR |
URLi ↑ MB, BR | Lispro ↑ MB, BR |
| Average glucose (mg/dL) | 166.8 ± 10.8 | 164.8 ± 10.2 | 163.3 ± 10.5 | 161.9 ± 10.3 | 160.4 ± 10.5 | 154.9 ± 11.2 |
| Coefficient of variation (%) | 30.2 ± 5.9 | 27.3 ± 5.4 | 27.5 ± 5.4 | 27.5 ± 5.4 | 27.6 ± 5.4 | 31.1 ± 5.6 |
| % time <54 mg/dL | 0.5 ± 0.7 | 0.3 ± 0.4 | 0.3 ± 0.5 | 0.3 ± 0.5 | 0.3 ± 0.5 | 0.9 ± 1.0 |
| % time <70 mg/dL | 1.8 ± 1.5 | 1.1 ± 1.1 | 1.2 ± 1.2 | 1.2 ± 1.2 | 1.3 ± 1.2 | 2.8 ± 2.0 |
| % time in 70 to 140 mg/dL | 32.3 ± 5.8 | 31.6 ± 5.8 | 32.9 ± 6.1 | 34.1 ± 6.2 | 35.5 ± 6.7 | 41.0 ± 8.2 |
| % time in 70 to 180 mg/dL | 62.4 ± 9.5 | 65.7 ± 9.8 | 66.7 ± 9.9 | 67.5 ± 10.1 | 68.5 ± 10.2 | 68.9 ± 10.4 |
| % time >180 mg/dL | 35.8 ± 8.9 | 33.3 ± 9.4 | 32.2 ± 9.5 | 31.3 ± 9.7 | 30.3 ± 9.8 | 28.3 ± 9.5 |
| % time >250 mg/dL | 7.8 ± 7.3 | 5.5 ± 6.3 | 5.2 ± 6.2 | 4.8 ± 6.0 | 4.5 ± 5.8 | 4.9 ± 5.7 |
| #Hypo-treatments | 8.0 ± 7.0 | 5.0 ± 5.0 | 5.0 ± 6.0 | 5.0 ± 6.0 | 6.0 ± 6.0 | 13.0 ± 9.0 |
Mean and standard deviation values are reported.
Abbreviations: URLi, ultra-rapid lispro; MB, meal bolus; BR, basal rate.