Table 3:

Proportion of participants with clinically meaningful improvement in average pain intensity and proportion endorsing any opioid analgesic medication use at each follow-up time by treatment group (no imputed data), and risk ratios comparing treatment groups

		Proportion (95% Confidence Interval)^a			P-value^b	Risk Ratio (95% Confidence Interval)^e
		ED	HYP	MM		HYP vs. ED	MM vs. ED	MM vs. HYP
Clinically Meaningful Responder (yes)	Post-treatment	0.16 (0.09, 0.24)	0.12 (0.06, 0.19)	0.20 (0.13, 0.29)	.29	0.75 (0.37, 1.51)	1.27 (0.69, 2.35)	1.70 (0.57, 2.83)
	3-months	0.17 (0.10, 0.26)	0.20 (0.13, 0.29)	0.18 (0.11, 0.27)	.80	1.20 (0.65, 2.19)	1.01 (0.52, 1.93)	0.84 (0.33, 1.36)
	6-months	0.09 (0.04, 0.17)	0.26 (0.18, 0.36)	0.22 (0.15, 0.32)	.02^*	2.85 (1.35, 6.00)^*	2.35 (1.09, 5.08)^*	0.83 (0.39, 1.26)
Using any opioid analgesic Medications (yes)	Post-treatment	0.24 (0.16, 0.33)	0.20 (0.13, 0.29)	0.22 (0.15, 0.32)	.003^*	1.40 (1.11, 1.78)^*	0.97 (0.69, 1.37)	0.69 (0.52, 0.86)^*
	3-months	0.23 (0.15, 0.33)	0.20 (0.13, 0.29)	0.26 (0.17, 0.36)	.05^*	1.28 (0.97, 1.68)	0.96 (0.67, 1.36)	0.75 (0.54, 0.96)^*
	6-months	0.25 (0.16, 0.35)	0.21 (0.14, 0.31)	0.24 (0.16, 0.34)	.18	1.17 (0.87, 1.57)	0.85 (0.58, 1.24)	0.73 (0.47, 0.98)

Denotes significance at p < .05

Proportions based on complete dataset, and Jeffreys 95% confidence intervals

P-value from omnibus test for treatment group effect on being a responder to treatment (adjusting for pretreatment average pain intensity) or using opioid analgesic medications (adjusting for use at pretreatment) in a logistic regression.

Risk ratio estimates from a logistic regression with log-link for a responder to treatment (adjusting for pretreatment average pain intensity) or using opioid analgesic medication at posttreatment (adjusting for use at pretreatment)