Table 4. Upregulated ataxia-related genes in MWK.

Tyrosine hydroxylase (Th) is ectopically upregulated MWK. Several of the listed genes were upregulated in P18 MWK mouse Cell type expression is based on Allen Brain Atlas ISH images and published papers. CN-cerebellar nuclei, BG-Bergman glia, GC-granule cells, GoC-Golgi cells, PC-Purkinje cells, S/BC-stellate and basket cells. The list shows genes with FDR Adjusted p < 0.003.

Official Symbol	Official Full Name (also known as)	Cell type expression	FDR Adj p Value	SCA models and mouse mutants	References
Opn3	opsin 3	PC	3.6E-72	upregulated in P18 MWK	Dulneva et al., 2015
Th	tyrosine hydroxylase	none	9.9E-45	ectopic PC expression in Nagoya mutant, tottering mice, pogo mice, Car8 KO, and PC specific VGAT mutant	Fureman et al., 2003; Jeong et al., 2001; Sawada and Fukui, 2010; White et al., 2014; White et al., 2016
Sv2c	synaptic vesicle glycoprotein	2c PC, CN	4.5E-28	upregulated in P18 MWK	Dulneva et al., 2015
Ryr3	ryanodine receptor 3	PC	1.8E-16	upregulated in Nagoya mouse; changed in SCA2	Arsović et al., 2020; Sawada et al., 2008
Prdx6	peroxiredoxin 6	PC	3.3E-11	upregulated in P18 MWK	Dulneva et al., 2015
Osbpl1a	oxysterol binding protein-like 1 A	not conclusive	4.8E-06	downregulated in P18 MWK	Dulneva et al., 2015
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (SERCA)	PC, GoC, CN	2.0E-05	downregulated in SCA1, SCA2 models and Atxn2 KO mouse	Arsović et al., 2020; Halbach et al., 2017; Lin et al., 2000
Inpp5a	inositol polyphosphate-5-phosphatase A	PC	3.6E-05	KO mouse; downregulated in SCA1, SCA2, SCA7, SCA17 models and Atxn2 KO mouse	Lin et al., 2000; Kasumu et al., 2012; Yang et al., 2015; Halbach et al., 2017; Shimobayashi and Kapfhammer, 2018; Arsović et al., 2020; Liu et al., 2020; Wu and Kapfhammer, 2022;
Camk2n1	calcium/calmodulin-dependent protein kinase II inhibitor 1	no data	1.2E-04	downregulated in SCA2 model	Arsović et al., 2020