Table 3.

Zero-inflated negative binomial regression analyses for number of prescriptions of analgesics in adolescence and young adulthood by symptoms as reported in adolescence.

	n	Opioids		Nonopioid analgesics
		Opioids		Paracetamol		NSAIDs
		IRR (95% CI)	P	IRR (95% CI)	P	IRR (95% CI)	P
Analgesics use in adolescence
Psychological distress	5807	1.06 (0.91, 1.24)	0.460	1.07 (0.87, 1.30)	0.537	1.07 (0.98, 1.16)	0.128
Posttraumatic stress symptoms	4753	1.05 (0.95, 1.40)	0.338	1.11 (0.99, 1.25)	0.064	1.13 (1.07, 1.19)	<0.001
Musculoskeletal pain	5790	1.35 (1.24, 1.47)	<0.001	1.56 (1.42, 1.72)	<0.001	1.29 (1.24, 1.35)	<0.001
Headaches	5447	1.54 (1.15, 2.06)	0.003	1.91 (1.35, 2.70)	<0.001	1.86 (1.60, 2.17)	<0.001
Analgesics use in young adulthood
Psychological distress	5954	1.48 (1.33, 1.64)	<0.001	1.26 (1.13, 1.42)	<0.001	1.17 (1.10, 1.25)	<0.001
Posttraumatic stress symptoms	4858	1.31 (1.23, 1.40)	<0.001	1.17 (1.09, 1.25)	<0.001	1.10 (1.06, 1.14)	<0.001
Musculoskeletal pain	5939	1.47 (1.39, 1.55)	<0.001	1.49 (1.40, 1.58)	<0.001	1.26 (1.22, 1.30)	<0.001
Headaches	5586	1.88 (1.54, 2.29)	<0.001	2.38 (1.94, 2.93)	<0.001	1.67 (1.48, 1.88)	<0.001

Subsample analysis among participants exposed to childhood trauma.

Complete case analyses adjusted for age, sex, household structure, and family economy. Analyses for analgesics use in adolescence were additionally adjusted for pubertal development.

IRR, incidence rate ratio; NSAIDs, nonsteroid anti-inflammatory drugs.