Table 3.
Mean Thickness of the Photoreceptor Inner and Outer Segments, RPE, Drusen, Subretinal Drusenoid Deposit (SDD), and Choroid Among Normal, Early, and Intermediate (Int) AMD Eyes (Classified by the Beckman Scale) for EDTRS Subfields
| Normal | Early AMD | Norm Versus Early | Int AMD | Norm Versus Int | Early Versus Int | ||
|---|---|---|---|---|---|---|---|
| N | 242 | 98 | P Value | P Value | 103 | P Value | |
| Layers | Age, Y | 70.7 ± 5.8 | 71.7 ± 6.2 | 0.38 | 73.4 ± 6.1 | <0.001 | 0.07 |
| Mean thickness (µm) | |||||||
| Photoreceptor inner | Entire EDTRS | 16.2 ± 0.09 | 16.0 ± 0.15 | 0.28 | 15.7 ± 0.12 | 0.004 | 0.19 |
| segments | Outer ring | 15.4 ± 0.09 | 15.2 ± 0.14 | 0.97 | 15.0 ± 0.11 | 0.02 | 0.63 |
| Inner ring | 18.4 ± 0.12 | 18.1 ± 0.19 | 0.77 | 17.8 ± 0.15 | 0.01 | 0.57 | |
| Central subfield | 20.6 ± 0.17 | 20.1 ± 0.26 | 0.38 | 19.8 ± 0.20 | 0.02 | 0.65* | |
| Photoreceptor outer | Entire EDTRS | 29.4 ± 0.22 | 28.7 ± 0.34 | 0.10* | 29.4 ± 0.27 | 0.88 | 0.10* |
| segments | Outer ring | 29.3 ± 0.23 | 28.6 ± 0.36 | 0.24 | 29.0 ± 0.28 | 0.78 | 0.39 |
| Inner ring | 29.4 ± 0.22 | 28.9 ± 0.34 | 0.78 | 30.5 ± 0.27 | 0.004 | <0.001 | |
| Central subfield | 31.0 ± 0.27 | 30.9 ± 0.43 | 0.67 | 33.0 ± 0.34 | <0.001 | <0.001 | |
| RPE +BL | Entire EDTRS | 34.5 ± 0.25 | 34.5 ± 0.25 | 0.51 | 33.7 ± 0.20 | 0.02 | 0.01 |
| Outer ring | 33.9 ± 0.17 | 34.2 ± 0.26 | 0.95 | 33.6 ± 0.21 | 0.94 | 0.24* | |
| Inner ring | 35.7 ± 0.17 | 35.6 ± 0.26 | 0.56 | 34.2 ± 0.21 | <0.001 | <0.001 | |
| Central subfield | 36.2 ± 0.20 | 35.6 ± 0.32 | 0.33 | 34.2 ± 0.25 | <0.001 | 0.003 | |
| Drusen | Entire EDTRS | 0.0 ± 0.06 | 0.0 ± 0.10 | 0.96 | 1.0 ± 0.08 | <0.001 | <0.001 |
| Outer ring | 0.0 ± 0.03 | 0.0 ± 0.04 | 0.87 | 0.4 ± 0.03 | <0.001 | <0.001 | |
| Inner ring | 0.1 ± 0.18 | 0.1 ± 0.28 | 0.88 | 2.6 ± 0.22 | <0.001 | <0.001 | |
| Central subfield | 0.1 ± 0.36 | 0.1 ± 0.57 | 0.65 | 4.7 ± 0.45 | <0.001 | <0.001 | |
| Subretinal drusenoid | Entire EDTRS | 0.0 ± 0.01 | 0.0 ± 0.02 | 0.9 | 0.1 ± 0.01 | <0.001 | <0.001 |
| deposit (SDD) | Outer ring | 0.0 ± 0.01 | 0.0 ± 0.02 | 0.78 | 0.1 ± 0.01 | <0.001 | <0.001 |
| Inner ring | 0.0 ± 0.01 | 0.0 ± 0.02 | 0.91 | 0.1 ± 0.01 | <0.001 | <0.001 | |
| Central subfield | 0.0 ± 0.01 | 0.0 ± 0.02 | 0.69 | 0.1 ± 0.02 | <0.001 | 0.01 | |
| Choroid | Entire EDTRS | 178.0 ± 2.93 | 180.9 ± 4.57 | 0.59* | 179.9 ± 3.6 | 0.69 | 0.85* |
| Outer ring | 174.7 ± 2.86 | 178.0 ± 4.46 | 0.34 | 177.1 ± 3.51 | 0.54 | 0.69* | |
| Inner ring | 187.9 ± 3.20 | 189.6 ± 4.99 | 0.64 | 187.8 ± 3.93 | 0.62 | 0.78* | |
| Central subfield | 190.7 ± 3.43 | 192.7 ± 5.36 | 0.15 | 190.0 ± 4.21 | 0.37 | 0.52* | |
*
Some significant differences among AREDS-stratified groups were no longer significant among Beckman-stratified groups (Table 2), as highlighted and marked by an asterisk (*).