Table 2.

Interrupted time series of weekly emergency medical service calls for mental health and overdose from January 2019 to July 2020, using negative binomial regression offset by the total population, for regions in the United Kingdom and Canada.^a

Outcome and variable		East Midlands region, United Kingdom	Niagara and Hamilton regions, Canada
Mental health
	Attendances, n	87,086	19,410
	Per week, IRRb (95% CI)	1.002 (1.002-1.003) c	0.999 (0.999-1.000)
	Lockdown, IRR (95% CI)	1.125 (1.031-1.227)	0.927 (0.802-1.073)
	Lockdown trend, IRR (95% CI)	0.998 (0.990-1.006)	1.003 (0.989-1.017)
Overdose
	Attendances, n	64,832	11,619
	Per week, IRR (95% CI)	1.002 (1.002-1.003)	1.002 (1.000-1.002)
	Lockdown, IRR (95% CI)	0.573 (0.518-0.635)	0.758 (0.615-0.936)
	Lockdown trend, IRR (95% CI)	1.031 (1.022-1.041)	1.015 (0.994-1.035)

^aModels have been adjusted for seasonality (each month as a variable).

^bIRR: incidence rate ratio.

^cIRRs statistically significant at P<.05 are indicated in italics format.