TABLE 2.
Comparison of Disease Progression Assessed by an Ordinal Outcome at 12, 24, 36, 48, and 60 Months for Patients With CC Without EV and PIT ≤ 150 × 109/L or PIT > 150 × 109/L, Respectively
| Observation Time, Months | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 12 | 24 | 36 | 48 | 60 | ||||||
| PLT × 109/L | ≤150 | >150 | 150 | >150 | ≤150 | >150 | ≤150 | >150 | ≤150 | >150 |
| Outcome grade | ||||||||||
| No. of patients | 101 | 101 | 101 | 101 | 101 | 101 | 101 | 101 | 101 | 101 |
| 1 = No prog | 96 | 98 | 74 | 86 | 66 | 81 | 64 | 78 | 56 | 73 |
| 2 = varices | 2 | 1 | 16 | 9 | 20 | 14 | 21 | 16 | 24 | 19 |
| 3 = Gl bleeding | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
| 4 = 1st decomp | 3 | 1 | 7 | 3 | 5 | 2 | 5 | 2 | 4 | 3 |
| 5 = 2nd decomp | 0 | 0 | 1 | 0 | 4 | 1 | 3 | 2 | 3 | 2 |
| 6 = death | 0 | 1 | 3 | 2 | 6 | 2 | 8 | 2 | 13 | 3 |
| Total events | 8 | 42 | 55 | 60 | 73 | |||||
| Total patients | 202 | 202 | 202 | 202 | 202 | |||||
| Statistical analysis | ||||||||||
| χ2; P(df = 5)† | 2.35; 0.5 | 6.7; 0.24 | 8.7; 0.12 | 8.14; 0.15 | 9.4; 0.09 | |||||
| OR (ordinal logistic)* | 0.59 (0.14-2.55) | 0.48 (0.24-0.96) | 0.45 (0.24-0.84) | 0.49 (0.26-0.89) | 0.45 (0.25-0.79) | |||||
| Wald test | 0.70 | 2.06 | 2.48 | 2.31 | 2.74 | |||||
| OR (binary logistic)* | 0.65 (0.11-4.03) | 0.51 (0.18-1.45) | 0.36 (0.13-0.98) | 0.39 (0.15-1.01) | 0.37 (0.16-0.86) | |||||
| Wald test | 0.45 | 1.25 | 2.01 | 1.94 | 2.31 | |||||
| Wald test ordinal/Wald test binary logistic regression | 1.56 | 1.65 | 1.23 | 1.19 | 1.19 | |||||
| Cox HR (binary composite outcome)‡ | 0.66 (0.11-3.95) | 0.54 (0.20-1.45) | 0.42 (0.16-1.09) | 0.45 (0.18-1.11) | 0.43 (0.19-0.94) | |||||
| Wald test | 0.46 | 1.23 | 1.79 | 1.74 | 2.12 | |||||
| Wald test ordinal/Wald test Cox model regression | 1.52 | 1.67 | 1.39 | 1.33 | 1.29 | |||||
ORs for progression in patients with higher versus lower PLTs are shown for an ordinal outcome in six grades (by ordinal logistic analysis) and for a dichotomization of the ordinal outcome at grade 2 (≤2 vs. >2, by binary logistic analysis); HRs by the Cox model are also reported with a composite outcome defined by death or any decompensating event, corresponding to grades ≤2 versus >2 of the ordinal outcome.
Bold delimited area includes outcome grades from 3 to 6.
95% CIs are reported in parentheses.
Overall chi-square test with 5 df (this test does not account for ordinality of outcome).
HR for the composite outcome defined by death or development of bleeding, first nonbleeding decompensation, or any second decompensation by the Cox model.
Abbreviation: df, degrees of freedom.