TABLE 3.

ORs of Disease Progression by Treatment Group in Our Emulated Trial, Analyzed for Each Increasing Grade in the Ordinal Outcome Progression Scale by Generalized Ordered Logistic Regression (Not Assuming Proportional Odds)

Treatment Response According to the Ordinal Outcome Grade (Y)	Odds	Clinical Translation of Odds	OR Comparing Patients With PLT > 150 × 109/L vs. PLT ≤ 150 × 109/L (95% CI)
1 = no progression	—	—	—
2 = varices	P(Y > 1)/P(Y = 1)	Any disease progression/no progression	0.48 (0.27, 0.86)*
3 = GI bleeding	P(Y > 2)/P(Y ≤ 2)	Decompensation or death/remaining compensated	0.37 (0.16, 0,86)*
4 = first decompensation	P(Y > 3)/P(Y ≤ 3)	First nonbleeding decompensation or death/remaining compensated or with bleeding alone	0.35 (0.15, 0.83)*
5 = any second decompensation	P(Y > 4)/P(Y ≤ 4)	Any second decompensation or death/remaining compensated or with any first decompensation	0.28 (0.10, 0.79)*
6 = death	P(Y > 5)/P(Y ≤ 5)	Death/alive	0.21 (0.06, 0.75)*

^*Chi-square (df = 4) = 2.65; P value = 0.6173. The lack of statistical significance among ORs for each increasing grade of the ordinal outcome confirms that the proportional odds model may be applied in this case.

Abbreviation: P, probability.