Table 2.

Criteria in the definition of porto-sinusoidal vascular disorder (adapted from¹⁹).

	Feature of portal hypertension	Histological lesions suggestive of porto-sinusoidal vascular disorder assessed by an expert pathologist
Specific	Gastric, oesophageal, or ectopic varices Portal hypertensive bleeding Portosystemic collaterals at imaging	Obliterative portal venopathy (thickening of vessel wall, occlusion of the lumen, vanishing of portal veins) Nodular regenerative hyperplasia Incomplete septal fibrosis (also called incomplete septal cirrhosis); this latter feature can only be assessed on liver explants and not on liver biopsies
Not specific	Ascites Platelet count <150,000/mm3 Spleen size ≥13 cm in the largest axis	Portal tract abnormalities (multiplication, dilatation of arteries, periportal vascular channels, aberrant vessels) Architectural disturbance: irregular distribution of the portal tracts and central veins Non-zonal sinusoidal dilatation Mild perisinusoidal fibrosis