Figure 1.

HMGB1 mRNA expression in pre-ICI-treatment FFPE tumor tissue samples. (A) Volcano plot indicating differential expression of the genes included in the IO360 panel. Genes depicted in green indicate a log2 Fold Change > 1, genes depicted in blue indicate a nominal p-value < 0.05, genes depicted in red indicate a log2 Fold Change > 1 and a p-value < 0.05. (B) Significantly differentially expressed genes between patients with and without clinical benefit, based on the Fold Change and nominal p-value (independent t-test). P-values adjusted for multiple testing are also included.

Abbreviations: CB, clinical benefit; ns, not significant; Adj. P-value, adjusted P-value.