Table 3.
Cohorts or biobanks with existing multi-omic data.
| Study characteristics | Omics | Follow-up outcomes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbreviation | Cohort | Location | Description/Note | Total N | Methylation | Metabolome | Prateome | Other | Time to death |
Cause of death |
Multi-morbidity | Other |
| UKB | UK Biobank | UK | Largest multi-omic dataset to date | > 500,000 | ✓ | ✓ | Transcriptome | ✓ | ✓ | ✓ | Cognitive function, Accelerometer | |
| LIFELINES | Lifelines | NL | Multigenerational European Cohort | >167,000 | ✓ | ✓ | ✓ | Microbiome | ✓ | ✓ | ✓ | Cognitive function |
| MGB | Mass General Biobank | USA | Leading hospital biobank | > 135,000 | ✓ | ✓ | ✓ | Lipidome | ✓ | ✓ | ✓ | |
| RS | Rotterdam Study | NL | Three cohorts focusing on mid- to late life | >15,000 | ✓ | ✓ | ✓ | Microbiome, Lipidome | ✓ | ✓ | ✓ | |
| MESA | Multi-Ethnic Study of Atheroscler osis | USA | Multi-ethnic population followed since 2000 | > 6,000 | ✓ | ✓ | ✓ | Transcriptome | ✓ | ✓ | ||
| CARDIA | Coronary Artery Risk Developme nt in Young Adults | USA | Population of mixed ethnicities followed from young adulthood (18-30) | > 5,000 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | Cognitive function | |
| HABC | Health, Aging and Body Composition Study | USA | Focus on functional decline and body composition | > 3,000 | ✓ | ✓ | ✓ | ✓ | ✓ | Cognitive function, Physical function, MRI | ||
| BLSA | Baltimore Longitudinal Study of Aging | USA | Comprehensive characterization of aging phenotypes | > 3,000 | ✓ | ✓ | ✓ | Microbiome | ✓ | ✓ | ✓ | Cognitive function, Physical function |
| AASK | African American Study of Kidney Disease and Hypertension | USA | African American population followed over time | 691 | ✓ | ✓ | ✓ | ✓ | ||||
| iPOP | Integrated Personal Omics Profiling | USA | Deep longitudinal profiling | >100 | ✓ | ✓ | ✓ | Microbiome, Lipidome | ✓ | ✓ | ✓ | |