TABLE 3.

HPV35 A1 and A2 sublineage associations with CIN2+ and CIN3+ from women in the Persistence and Progression (PaP) Cohort at Kaiser Permanente Northern California by a women’s ethnicity

Ethnicity/sublineage	Controls (%)	CIN2+ (%)	OR (95% CI)	CIN3+ (%)	OR (95% CI)
All ethnic/multiethnic groups
A1	250 (84.2)	192 (89.7)	ref	59 (85.5)	ref
A2	47 (15.8)	22 (10.3)	0.6 (0.3-1.0)	10 (14.5)	0.9 (0.4-1.9)
White
A1	101 (83.5)	111 (97.4)	ref	33 (97.1)	ref
A2	20 (16.5)	3 (2.6)	0.1 (0.0-0.5)	1 (2.9)	0.2 (0.0-1.2)
Hispanic
A1	50 (83.3)	24 (82.8)	ref	10 (76.9)	ref
A2	10 (16.7)	5 (17.2)	1.0 (0.3-3.4)	3 (23.1)	1.5 (0.4-6.5)
Asian
A1	31 (91.2)	18 (90.0)	ref	9 (90.0)	ref
A2	3 (8.8)	2 (10.0)	1.2 (0.2-7.5)	1 (10.0)	1.2 (0.1-12.4)
African-American
A1	45 (81.8)	34 (75.6)	ref	4 (44.4)	ref
A2	10 (18.2)	11 (24.4)	1.5 (0.5-3.8)	5 (55.6)	5.6 (1.3-24.8)
P-value (Wald-test)			0.02		0.05

Note: For these analyses, there were no age restrictions. The only restriction was HPV16 co-infections. Among CIN2+ and CIN3+ cases, the distribution of A1/A2 significantly varied by ethnicity (Chi-square tests, P < .001 and P < .01, respectively). Among controls, the distribution of A1/A2 did not significantly differ by ethnicity (Chi-square tests, P = .7). Bold indicates P-value < .05 for logistic regression and Wald-test for heterogeneity.

Abbreviations: CIN2+, cervical intraepithelial neoplasia (CIN) grade 2, CIN grade 3 and cancer; CIN3+, CIN grade 3 and cancer; OR, odds ratio; 95% CI, 95% confidence intervals from logistic regression.