TABLE 4.
HPV35 A1 and A2 sublineage distribution among ICC, abnormal lesions and benign infections by world region using IARC specimens
| Sublineages Regions | Benign infections |
HSIL/CIN2/CIN3 |
ICC |
P-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | % | 95% CI | n | % | 95% CI | n | % | 95% CI | ||
| Non-Africa | ||||||||||
| A1 | 93 | 94.9 | 88.6-97.8 | 15 | 93.8 | 71.7-99.7 | 43 | 89.6 | 77.8-95.5 | |
| A2 | 5 | 5.1 | 2.2-11.4 | 1 | 6.3 | 0.3-28.3 | 5 | 10.4 | 4.5-22.2 | .46a |
|
| ||||||||||
| Africa | ||||||||||
| A1 | 62 | 45.9 | 37.7-54.3 | 8 | 57.1 | 32.6-78.6 | 18 | 58.1 | 40.8-73.6 | |
| A2 | 73 | 54.1 | 45.7-62.3 | 6 | 42.9 | 21.4-67.4 | 13 | 41.9 | 26.4-59.2 | .39a |
|
| ||||||||||
| P-value | <.0001 b | .03 a | <.01 b | |||||||
Note: For this analysis, samples from Sub-Saharan Africa were considered “Africa” and samples from North Africa were included with the other world regions as “Non-Africa”. Bold indicates P-value < .05 for
a
Fisher’s exact test and
b
Chi-square test.
Abbreviations: CIN2, Cervical intraepithelial neoplasia (CIN) grade 2; CIN3, CIN grade 3; HSIL, high-grade squamous intraepithelial lesion; ICC, invasive cervical cancers.