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. 2024 Mar 7;56(4):586–596. doi: 10.3724/abbs.2024002

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© The Author(s) 2021.

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).

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Overexpression of SirT7 inhibited EndMT and improved renal dysfunction in DN rats

(A) HE staining, Masson staining, and IHC results for α-SMA, CD31, fascin and SirT7 expressions in the kidneys of the rats after the corresponding treatment. (B) Western blot analysis results showing the expressions of α-SMA, CD31, fascin and SirT7 in the kidneys of the rats after the corresponding treatment. (C) qPCR results showing SirT7 expression in the kidneys of the rats after the corresponding treatment. (D) qPCR results of fascin in the kidneys of the rats with the corresponding treatment. (E) qPCR results showing CD31 expression in the kidneys of the rats with the corresponding treatment. (F) qPCR analysis of α-SMA expression in the kidneys of the rats with the corresponding treatment (*P<0.05, **P<0.01, ***P<0.001, ****P<0.0001; n=5).