Table 1.
Quantitative PCR analysis of mRNA extracted from whole brains of WT and Dp(16)1Yey pups on P6
| mRNA level (%) | Vehicle-treated WT (n = 4) | sPIF-treated WT (n = 4) | Vehicle-treated Dp(16)1Yey (n = 4) | sPIF-treated Dp(16)1Yey (n = 4) |
|---|---|---|---|---|
| Bax | 100 ± 4 | 54 ± 6£ | 93 ± 19 | 58 ± 5$ |
| Bcl2 | 100 ± 4 | 53 ± 7££ | 90 ± 17 | 53 ± 7$ |
| cIPA2 | 100 ± 5 | 72 ± 7£ | 94 ± 8 | 69 ± 10$ |
| Cyclin D1 | 100 ± 6 | 83 ± 12 | 73 ± 4* | 121 ± 3$$ |
| Dyrk1a | 100 ± 21 | 104 ± 24 | 183 ± 31* | 116 ± 18$ |
| Gli2 | 100 ± 17 | 56 ± 12£ | 65 ± 10* | 120 ± 12$ |
| Iba1 | 100 ± 25 | 101 ± 13 | 174 ± 23* | 121 ± 22$ |
| IκBα | 100 ± 5 | 73 ± 5£ | 140 ± 13*** | 102 ± 4$$ |
| IL-6 | 100 ± 9 | 67 ± 3£ | 147 ± 11** | 108 ± 14$ |
| p65 | 100 ± 6 | 75 ± 9 | 122 ± 5* | 99 ± 10$ |
| S100B | 100 ± 10 | 78 ± 8£ | 155 ± 15*** | 110 ± 8$ |
Data are expressed as the mean ± SD and were analyzed in a two-way ANOVA followed by Fisher’s least squares difference test. ** p < 0.01 and *** p < 0.005 (sPIF-treated WT or vehicle-treated Dp(16)1Yey vs. vehicle-treated WT); $p < 0.05 (sPIF-treated Dp(16)1Yey vs. vehicle-treated Dp(16)1Yey); £p < 0.05 and ££p < 0.01 (sPIF-treated WT vs. vehicle-treated WT).