Figure 3. Viral dynamics during the first two weeks after symptom onset by nirmatrelvir/ritonavir treatment completion and viral load rebound¹ visualized by (A) cumulative probability of RT-PCR conversion to negative², (B) median viral load each day since symptom onset and proportion with viral load rebound, and (C) median of each participant’s average daily viral load after nirmatrelvir/ritonavir completion or seven days since symptom onset.

Footnote: N/R=nirmatrelvir/ritonavir;

¹VL rebound was defined as an increase of at least 1 log₁₀IU/mL for which the maximum VL exceeded 5 log₁₀IU/mL after treatment completion/proxy;

²PCR conversion was defined as the first day in which a patient had a negative PCR result after which no additional positive results occurred.