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Effect of vaccine-induced antibody response on breakthrough COVID-19 outcomes
| Exposure | Breakthrough outcomes | Number of HLA alleles | Relative risk (95% CI) | Effectiveness (95% CI) |
|---|---|---|---|---|
| First-dose antibody response | COVID-19 infection | 6 | 0.83 (0.74 to 0.94) | 16.84 (6.39 to 26.12) |
| Severe COVID-19 | 6 | 0.55 (0.36 to 0.84) | 49.94 (15.52 to 70.34) | |
| Second-dose antibody response | COVID-19 infection | 2 | 0.78 (0.65 to 0.94) | 21.68 (5.99 to 34.76) |
| Severe COVID-19 | 2 | 0.54 (0.28 to 1.01) | 46.44 (−1.49 to 71.73) |
