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. 2024 May 13;14:10896. doi: 10.1038/s41598-024-61611-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differences in therapeutic response according to radiological features in each number of recurrences. (a) Proportion of therapeutic response according to radiological features in each number of recurrences. (b) Comparison of TTUP between initial occurrence and recurrence in patients with infiltrative HCCs. ROC analysis for predicting treatment refractoriness and comparison of cut-off values of the sum of the diameter of the largest tumor (in centimeter) and the number of tumors for predicting treatment refractoriness in (c) all patients, (d) initial occurrence vs recurrence, (e) 1–2 recurrence vs 3- recurrence. Asterisks indicate statistically significant differences of means (0.01 ≤ * P < 0.05; 0.001 ≤ ** P < 0.01; *** P < 0.001). TTUP: time to untreatable untraceable progression, HCCs: hepatocellular carcinomas. ROC: receiver operating characteristic. Asterisks indicate statistically significant differences of means (0.01 ≤ * P < 0.05; 0.001 ≤ ** P < 0.01; *** P < 0.001). TTUP: time to untreatable progression by TACE, HCCs: hepatocellular carcinomas.