Table 3.
(Left) PCA loading scores, the highest values for each PC are highlighted in bold, (right) univariate CPH results for each clinical variable.
Features | PC1 | PC2 | PC3 | PC4 |
---|---|---|---|---|
Age | 0.397 | 0.050 | 0.251 | 0.024 |
Albumin | 0.382 | 0.018 | 0.115 | 0.131 |
AVR type | 0.377 | 0.161 | 0.288 | 0.111 |
Crockoft-gault eGFR | 0.347 | 0.241 | 0.115 | 0.313 |
Hemoglobin | 0.223 | 0.154 | 0.222 | 0.264 |
LV EF(%) | 0.195 | 0.296 | 0.226 | 0.149 |
BMI | 0.191 | 0.024 | 0.194 | 0.503 |
ASCVD | 0.180 | 0.272 | 0.096 | 0.290 |
Smoking | 0.175 | 0.147 | 0.286 | 0.218 |
Atrial fibrillation | 0.169 | 0.182 | 0.102 | 0.197 |
CHIP | 0.161 | 0.070 | 0.165 | 0.008 |
Glucose | 0.151 | 0.159 | 0.288 | 0.171 |
LDL | 0.141 | 0.010 | 0.181 | 0.287 |
Mean aortic gradient | 0.068 | 0.241 | 0.297 | 0.136 |
Sex | 0.053 | 0.427 | 0.344 | 0.039 |
Hypertension | 0.016 | 0.083 | 0.244 | 0.469 |
Features | p-value | c-index | logrank test | |
---|---|---|---|---|
AVR type | 0.221 | 0.54 | 0.21 | |
Sex | 0.085 | 0.60 | 0.09 | |
Age | 0.010 | 0.65 | – | |
BMI | 0.008 | 0.70 | – | |
Smoking status | 0.124 | 0.59 | 0.15 | |
Hypertension | 0.047 | 0.57 | 0.09 | |
Atherosclerotic cardiovascular disease | 0.374 | 0.54 | 0.40 | |
Atrial fibrillation/flutter | 0.832 | 0.51 | 0.83 | |
Hemoglobin | 0.051 | 0.61 | – | |
Glucose | 0.017 | 0.57 | – | |
Crockoft-gault eGFR | 0.470 | 0.57 | – | |
Albumin | 0.003 | 0.71 | – | |
LDL | 0.191 | 0.59 | – | |
LV-EF% | 0.340 | 0.55 | – | |
Mean aortic gradient | 0.713 | 0.47 | – | |
CHIP | 0.039 | 0.59 | 0.03 |
The statistically significant values (p-value < 0.05) are in bold.