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. 2024 May 13;14:10868. doi: 10.1038/s41598-024-61691-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IP analysis of CAA Aβ fibrils extracted from AD leptomeningeal tissues. CAA Aβ fibrils were isolated from the indicated four AD subjects and IP was conducted using the indicated antibody concentrations before eluate analysis using the V-PLEX^® Aβ peptide panel 1 (4G8) kit. (a) Eluate Aβ40 levels are presented as the median ± range, with each open circle representing an individual experiment. (b) The estimated EC₅₀ values for each individual and antibody (left-hand panel) and comparison of mean EC₅₀ values for the indicated antibodies (right-hand panel). A statistically significant ANOVA (F_4.8 = 58.93, p = 0.00001) was followed by Tukey’s unequal N post-hoc testing; **p < 0.01, ***p < 0.001. (c) Eluate Aβ40 levels (mean ± SD), with each open circle representing an individual experiment.