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. 2024 Apr 23;35(2):102198. doi: 10.1016/j.omtn.2024.102198

Figure 1.

Figure 1

Selection of aptamer by HT-SELEX

(A) SELEX procedure scheme. (B) Six rounds of SELEX were performed. During each round of SELEX, the concentration of the aptamer library was decreased by a factor of 3, by increasing the volume of the binding step. (C) Several candidate aptamers were enriched after selection. The variable regions of the 11 most enriched aptamers are depicted above. Shared motifs in the aptamer sequences are highlighted. (D) Motifs shared among candidate aptamers were enriched in the Round 6 SELEX library. (E) Phylogenetic tree depicting the distribution of candidate CD3 aptamers. Graphical representation of candidate aptamers according to degree of similarities and differences in their nucleotide sequences. Similar species are clustered in families represented by each arm of the tree.