Table 2.
Parameters of WT and T592I Nav1.4 channel variants
| Parameter | p.T592I | Wild-type | |
| Activation voltage-dependence | aV50 (mV) | –45.5±1.5 (n = 26) * | –40.9±1.0 (n = 15) |
| Ka (mV) | 3.8±0.2 | 3.4±0.4 | |
| Fast inactivation voltage- dependence | fV50 (mV) | –73.3±1.4 (n = 26) | –72.6±1.6 (n = 15) |
| Kf (mV) | –6.1±0.3 | –5.7±0.3 | |
| Open probability | Window current | 0.64±0.09 (n = 26) * | 0.34±0.07 (n = 15) |
| Slow inactivation voltage-dependence | sV50 (mV) | –69.7±2.5 (n = 16) | –68.7±2.6 (n = 22) |
| Ks (mV) | –8.6±0.6 | –9.3±0.6 | |
| I R | 0.21±0.02 | 0.21±0.01 |
The fit parameters were calculated as shown in Fig. 5, and reported as mean±S.E.M. from n cells. Statistical analysis was performed using unpaired Student’s t test. Significant differences were found between T592I and WT for activation voltage dependence midpoint ( *p < 0.05) and window current ( *p < 0.02). The aV50, fV50, and sV50 are the half-maximum potentials; Ka, Kf, and Ks are the slope factors; IR is the steady fraction of non-inactivating channels.