Table 1.
Significant genes correlated with FAM222A in brain tissues and present in Alzheimer’s disease related pathways
| Gene | Tissue | Pearson Correlation Coefficient | p | Sample Size | Pathway | Functional Category |
| ABCG1 | BRNSNG | 0.30 | 1.15E-06 | 114 | Amyloid precursor protein metabolic process; Amyloid precursor protein catabolic process | Biological Process |
| APOE | BRNNCC | 0.30 | 1.60E-06 | 202 | Amyloid precursor protein metabolic process; Amyloid precursor protein catabolic process; Alzheimer disease; Amyloid plaque; Alzheimer disease specific cell type; Amyloid-beta complex; Positive regulation of amyloid fibril formation | Biological Process; KEGG pathway; Tissue expression; Subcellular localization. |
| ATG101 | BRNHPP | 0.33 | 1.90E-06 | 165 | Alzheimer disease | KEGG Pathway |
| ATP2A3 | BRNCHB | 0.67 | 2.35E-14 | 175 | Alzheimer disease | KEGG Pathway |
| AXIN1 | BRNCTXA | 0.54 | 5.03E-10 | 205 | Alzheimer disease | KEGG Pathway |
| BACE1 | BRNCTXA | 0.41 | 2.24E-06 | 205 | Amyloid precursor protein metabolic process; Amyloid precursor protein catabolic process; Alzheimer disease; Amyloid plaque; Alzheimer disease specific cell type; Amyloid-beta complex | Biological Process; KEGG pathway; Tissue expression; Subcellular localization. |
| BCL11A | BRNCHB | –0.51 | 1.00E-06 | 175 | Regulation of protein oligomerization | Biological Process |
| CALM2 | BRNPTM | –0.54 | 1.92E-08 | 170 | Alzheimer disease | KEGG Pathway |
| CAPN2 | BRNSPC | 0.41 | 2.08E-07 | 126 | Alzheimer disease | KEGG Pathway |
| CLU | BRNSPC | –0.27 | 1.84E-06 | 126 | Neurofibrillary tangle; Positive regulation of amyloid fibril formation | Cellular Component; Subcellular Localization; Biological Process |
| FZD3 | BRNHPT | 0.35 | 3.94E-07 | 170 | Alzheimer disease | KEGG Pathway |
| GRIN2B | BRNCHB | –0.47 | 1.94E-06 | 175 | Alzheimer disease | KEGG Pathway |
| IRS1 | BRNSNG | –0.41 | 5.93E-07 | 114 | Alzheimer disease | KEGG Pathway |
| ITPR1 | BRNCHB | 0.47 | 1.29E-06 | 175 | Alzheimer disease | KEGG Pathway |
| KIF5A | BRNAMY | –0.58 | 2.90E-08 | 129 | Alzheimer disease | KEGG Pathway |
| KIF5B | BRNAMY | –0.62 | 1.74E-09 | 129 | Alzheimer disease | KEGG Pathway |
| KIF5C | BRNAMY | –0.52 | 1.62E-06 | 129 | Alzheimer disease | KEGG Pathway |
| LDLRAP1 | BRNAMY | 0.46 | 3.87E-08 | 129 | Amyloid precursor protein metabolic process | Biological Process |
| LDLRAP1 | BRNHPP | 0.36 | 1.49E-06 | 165 | Amyloid precursor protein metabolic process | Biological Process |
| MTOR | BRNCHA | –0.35 | 2.64E-08 | 209 | Alzheimer disease | KEGG Pathway |
| NEFH | BRNCHB | –0.38 | 4.22E-06 | 175 | Neurofibrillary tangle | Cellular Component; Subcellular Localization |
| NEFM | BRNSNG | –0.32 | 5.37E-06 | 114 | Neurofibrillary tangle | Cellular Component; Subcellular Localization |
| PIK3R4 | BRNAMY | –0.54 | 6.12E-07 | 129 | Alzheimer disease | KEGG Pathway |
| PSEN1 | BRNAMY | 0.46 | 2.98E-06 | 129 | Positive regulation of amyloid fibril formation; Amyloid precursor protein metabolic process; Amyloid precursor protein catabolic process; Alzheimer disease; Amyloid plaque; Alzheimer disease specific cell type; Neurofibrillary tangle; Amyloid-beta complex | Biological Process; KEGG Pathway; Tissue Expression; Subcellular Localization |
| PSEN2 | BRNAMY | –0. | 2.22E-06 | 129 | Amyloid precursor protein metabolic process; Amyloid precursor protein catabolic process; Alzheimer’s disease; Alzheimer’s disease specific cell type; Amyloid-beta complex | Biological Process; KEGG pathway; Tissue Expression; Subcellular Localization. |
| PSMD12 | BRNCDT | –0.31 | 1.04E-06 | 194 | Alzheimer disease | KEGG Pathway |
| RTN4 | BRNPTM | 0.33 | 1.08E-06 | 170 | Alzheimer disease | KEGG Pathway |
| TUBA1A | BRNPTM | 0.32 | 1.67E-06 | 170 | Alzheimer disease | KEGG Pathway |
| TUBB2B | BRNSPC | –0.44 | 1.82E-08 | 126 | Alzheimer disease | KEGG Pathway |
| VPS35 | BRNAMY | –0.45 | 1.21E-07 | 129 | Regulation of protein oligomerization | Biological Process |
| WNT16 | BRNCHB | 0.37 | 2.95E-08 | 175 | Alzheimer disease | KEGG Pathway |
| ZDHHC1 | BRNCHA | 0.33 | 1.06E-06 | 209 | Regulation of protein oligomerization | Biological Process |
BRNSNG, Brain - Substantia nigra; BRNNCC, Brain - Nucleus accumbens (basal ganglia); BRNHPP, Brain - Hippocampus; BRNCHB, Brain - Cerebellar hemisphere; BRNCTXA, Brain - Cortex; BRNPTM, Brain - Putamen (basal ganglia); BRNSPC, Brain - Spinal cord (cervical c-1); BRNHPT, Brain - Putamen (basal ganglia); BRNAMY, Brain - Amygdala; BRNCHA, Brain - Cerebellum; BRNCDT, Brain - Caudate (basal ganglia).