Table 2.
AD pathway genes identified to be significantly correlated with FAM222A expression levels in ACT study
| TCx | FWM | HIP | PCx | |||||
| Gene | Correlation Coefficient | p | Correlation Coefficient | p | Correlation Coefficient | p | Correlation Coefficient | p |
| ABCG1 | 0.49 | 2.93E-07 | 0.61 | 5.96E-11 | 0.49 | 4.09E-07 | 0.53 | 5.22E-08 |
| APOE | –0.09 | 4.00E-01 | 0.41 | 3.64E-05 | 0.21 | 4.12E-02 | 0.18 | 9.36E-02 |
| ATP2A3 | –0.06 | 5.83E-01 | 0.25 | 1.54E-03 | 0.24 | 2.19E-03 | –0.11 | 2.89E-01 |
| AXIN1 | 0.36 | 2.70E-04 | 0.54 | 2.07E-08 | 0.37 | 2.69E-04 | 0.40 | 1.01E-04 |
| BACE1 | 0.50 | 1.11E-07 | 0.73 | 8.67E-17 | 0.33 | 1.16E-03 | 0.63 | 3.03E-11 |
| BCL11A | –0.19 | 6.07E-02 | –0.79 | 2.05E-21 | –0.07 | 5.24E-01 | –0.20 | 5.26E-02 |
| CALM2 | –0.31 | 1.93E-03 | –0.13 | 2.12E-01 | –0.27 | 7.33E-03 | –0.15 | 1.59E-01 |
| CAPN2 | 0.15 | 1.34E-01 | 0.47 | 2.54E-06 | 0.12 | 2.42E-01 | 0.07 | 5.26E-01 |
| CLU | –0.05 | 6.12E-01 | –0.42 | 3.51E-05 | 0.02 | 8.66E-01 | –0.01 | 9.59E-01 |
| GRIN2B | –0.47 | 1.07E-06 | –0.83 | 7.28E-25 | –0.39 | 1.22E-04 | –0.50 | 3.59E-07 |
| IRS1 | 0.13 | 1.93E-01 | –0.68 | 4.42E-14 | –0.24 | 1.77E-02 | –0.10 | 3.42E-01 |
| KIF5A | 0.09 | 3.86E-01 | –0.69 | 1.43E-14 | 0.07 | 5.21E-01 | –0.11 | 2.90E-01 |
| KIF5B | –0.50 | 1.06E-07 | –0.56 | 5.97E-09 | –0.40 | 5.82E-05 | –0.36 | 4.95E-04 |
| KIF5C | –0.16 | 1.08E-01 | –0.38 | 1.48E-04 | –0.21 | 4.36E-02 | –0.25 | 1.59E-02 |
| LDLRAP1 | 0.66 | 1.40E-13 | 0.73 | 1.61E-16 | 0.67 | 1.36E-13 | 0.75 | 1.53E-17 |
| MTOR | –0.19 | 5.68E-02 | –0.46 | 3.17E-06 | –0.16 | 1.23E-01 | –0.07 | 4.90E-01 |
| NEFH | –0.06 | 5.51E-01 | –0.63 | 9.10E-12 | –0.10 | 3.46E-01 | –0.10 | 3.66E-01 |
| NEFM | –0.17 | 9.95E-02 | –0.74 | 4.81E-17 | –0.05 | 6.34E-01 | –0.17 | 1.05E-01 |
| PSEN1 | 0.61 | 1.34E-11 | 0.81 | 1.43E-22 | 0.49 | 6.52E-07 | 0.64 | 8.43E-12 |
| PSEN2 | –0.24 | 1.78E-02 | –0.68 | 5.16E-14 | –0.26 | 1.01E-02 | –0.06 | 5.57E-01 |
| PSMD12 | –0.35 | 4.66E-04 | –0.66 | 4.21E-13 | –0.41 | 3.44E-05 | –0.39 | 1.08E-04 |
| TUBA1A | 0.07 | 4.63E-01 | 0.57 | 2.10E-09 | 0.01 | 9.29E-01 | 0.29 | 5.54E-03 |
| VPS35 | –0.36 | 2.20E-04 | –0.71 | 9.16E-16 | –0.45 | 4.19E-06 | –0.39 | 1.40E-04 |
| WNT16 | 0.17 | 9.94E-02 | 0.61 | 7.55E-11 | 0.02 | 8.32E-01 | 0.24 | 2.14E-02 |
| ZDHHC1 | 0.09 | 3.95E-01 | 0.45 | 7.81E-06 | 0.01 | 9.08E-01 | 0.10 | 3.22E-01 |
TCx, temporal neocortex; FWM, white matter of forebrain; HIP, hippocampus; PCx, parietal neocortex.