Fig. 3.

Bar plot showing opposite patterns of TSPO expression/microglial activation (PBR PET SUVr) in inferior colliculi and cerebral cortex in 8 AD subjects versus 20 healthy controls. In inferior colliculi, TSPO expression was lower in AD subjects as compared to controls (p = 0.004). This is a novel finding. In cerebral cortex, TSPO expression was greater in AD subjects as compared to controls (p = 0.04). This is in accord with several prior studies [5–7]. PBR PET SUVr is calculated over bilateral regions. Error bars = 95% confidence intervals.