Fig. 4.

DMD mutations spots associated with later loss of ambulation in DMD. Note: Deletion of exons 3–7 vs. other out-of-frame deletion [16, 48]. Exon 8 skipping amenable deletion vs. other exon skippable [23, 48]. Proximal (mutation upstream intron 44) vs. distal (mutation intron 44 and downstream) [30]. Exon 44 skipping amenable deletion vs. other out-of-frame deletion or other exon skippable [16, 23, 44, 48, 51]. Single exon 45 deletions vs. other mutations [48]. Exon 53 skipping amenable deletion vs. other deletion [40]. Nonsense mutations vs. other deletions were also associated with later loss of ambulation [51] (not shown in figure).