Table 2. In Vitro Cytotoxicity of Analogs (10–24) Against the HCT-116/L Cell Line.

compounds	R3	R4	R5	R6	GI50(nM)
10	CH3	H	H	H	141 ± 27
11	H	CH3	H	H	30 ± 5
12	H	H	CH3	H	24 ± 5
13	H	H	H	CH3	16 ± 3
14	H	F	H	H	7 ± 1
15 (FC116)	H	H	F	H	6 ± 1
16	H	Cl	H	H	17 ± 2
17	H	Br	H	H	>10000
18	H	NO2	H	H	71 ± 5
19	H	H	NO2	H	15 ± 1
20	H	H	H	NO2	24 ± 3
21	H	H	NH2	H	27 ± 3
22	H	H	OCH3	H	47 ± 2
23	H	H	COOCH3	H	151 ± 19
24	H	H	COOH	H	>10000
oxaliplatin					77213 ± 2041