Table 3.
Associations between plasma and IgG N-glycan traits and AIH as compared to healthy controls. Logistic regression was performed between AIH (1) and HC (0), including age, sex and their interaction as co-variates. Only significant associations that passed the set log2 odds ratio threshold (Fig. 2A) are shown. The results of all tests can be found in Supplementary Table 5. To account for multiple testing, p-values have been corrected by the Benjamini-Hochberg procedure using a 5% FDR.
| Derived traits | Description | p-value (age and sex corrected) | Odds ratio [95% CI] (age and sex corrected) | Beta coefficient | Standard error |
|---|---|---|---|---|---|
| Glycan type | |||||
| MHy | High mannose to hybrid-type ratio | 1.62E-03 | 0.34 [0.2–0.56] | -1.06 | 0.27 |
| THy | Total hybrid within total | 2.31E-03 | 2.73 [1.67–4.89] | 1.01 | 0.27 |
| TA2FG0S0 | Total fucosylated nongalactosylated nonsialylated A2 | 2.72E-03 | 18.55 [4.7-112.74] | 2.92 | 0.81 |
| TA2FS0 | Total fucosylated nonsialylated A2 | 4.41E-03 | 3.3 [1.76–7.09] | 1.19 | 0.35 |
| Bisection | |||||
| CB | Of complex-type | 5.88E-03 | 3.78 [1.88–9.35] | 1.33 | 0.41 |
| A2B | Of A2 | 6.10E-03 | 3.45 [1.79–7.99] | 1.24 | 0.38 |
| A2SB | Of sialylated A2 | 1.40E-02 | 2.76 [1.52–5.89] | 1.01 | 0.34 |
| A2FB | Of fucosylated A2 | 1.63E-03 | 3.21 [1.87–6.16] | 1.17 | 0.30 |
| A2FSB | Of fucosylated sialylated A2 | 2.72E-03 | 2.72 [1.65–4.96] | 1.00 | 0.28 |
| A2S0B | Of nonsialylated A2 | 2.23E-03 | 2.93 [1.74–5.39] | 1.08 | 0.29 |
| A2F0S0B | Of nonfucosylated nonsialylated A2 | 4.28E-03 | 2.57 [1.55–4.65] | 0.94 | 0.28 |
| A2F0B | Of nonfucosylated A2 | 2.12E-02 | 2.93 [1.49–6.89] | 1.08 | 0.39 |
| A2FS0B | Of nonfucosylated sialylated A2 | 2.72E-03 | 2.71 [1.64–4.86] | 1.00 | 0.28 |
| Galactosylation | |||||
| CG | Of complex-type | 2.72E-03 | 0.06 [0.01–0.22] | -1.19 | 0.35 |
| A2G | Of A2 | 2.77E-03 | 0.18 [0.06–0.42] | -1.70 | 0.48 |
| A2FG | Of fucosylated A2 | 1.60E-03 | 0.28 [0.14–0.49] | -1.27 | 0.31 |
| A2SG | Of sialylated A2 | 1.31E-02 | 0.33 [0.15–0.63] | -1.10 | 0.37 |
| A2S0G | Of nonsialylated A2 | 1.60E-03 | 0.31 [0.17–0.52] | -1.17 | 0.29 |
| A2FSG | Of fucosylated sialylated A2 | 2.72E-03 | 0.38 [0.21–0.62] | -0.97 | 0.27 |
| A2FS0G | Of fucosylated nonsialylated A2 | 1.60E-03 | 0.32 [0.18–0.54] | -1.13 | 0.28 |
| A2F0S0G | Of nonfucosylated nonsialylated A2 | 4.28E-03 | 0.35 [0.18–0.61] | -1.04 | 0.30 |
| Sialylation | |||||
| CS | Of complex-type | 4.28E-03 | 0.3 [0.14–0.57] | -1.19 | 0.35 |
| A4S | Of A4 | 2.25E-03 | 2.7 [1.66–4.74] | 0.99 | 0.27 |
| A4GS | Per galactose on A4 | 1.63E-03 | 2.88 [1.75–5.16] | 1.06 | 0.27 |
| A4F0GS | Per galactose on nonfucosylated A4 | 2.72E-03 | 2.73 [1.64–4.92] | 1.00 | 0.28 |
| IgG glycosylation derived traits | |||||
| IgG1 bisection | IgG1 bisection | 1.63E-03 | 2.55 [1.63–4.22] | 0.94 | 0.24 |
| IgG1 galactosylation | IgG1 galactosylation | 3.47E-05 | 0.21 [0.11–0.37] | -1.55 | 0.30 |
| IgG1 sialylation | IgG1 sialylation | 1.52E-04 | 0.28 [0.16–0.45] | -1.29 | 0.27 |
| IgG1 antennary fucosylation | IgG1 antennary fucosylation | 1.62E-03 | 0.34 [0.19–0.56] | -1.07 | 0.27 |
| IgG2/3 galactosylation | IgG2/3 galactosylation | 1.62E-03 | 0.35 [0.2–0.58] | -1.04 | 0.26 |
CI: confidence interval