Table 3. Association of cyclin D1 regarding clinical-histopathological features.
| Variables | Cyclin D1 | p-value* | |
|---|---|---|---|
| Negative (−) | Positive (+) | ||
| Phimosis (N = 77) | |||
| Absent | 11 | 14 | 0.6 |
| Present | 20 | 32 | |
| Surgery type | |||
| Glansectomy/partial penectomy | 29 | 44 | 0.17 |
| Total penectomy | 15 | 12 | |
| Size of lesion (N = 99) | |||
| 0.6–5.0 cm | 25 | 37 | 0.53 |
| 5.1–10 cm | 18 | 19 | |
| HPV-associated histological subtype (N = 81) | |||
| Non-associated | 4 | 33 | 0.001 |
| Associated | 23 | 21 | |
| Differentiation grade | |||
| G1/G2 | 18 | 25 | 0.014 |
| G3 | 11 | 46 | |
| Perineural invasion | |||
| No | 23 | 39 | 0.023 |
| Yes | 6 | 32 | |
| Tumoral focus | |||
| Unifocal | 35 | 50 | 0.25 |
| Multifocal | 9 | 6 | |
| Presence of carcinoma in situ | |||
| No | 6 | 11 | 0.59 |
| Yes | 38 | 45 | |
| Sarcomatoid transformation | |||
| No | 39 | 40 | 0.04 |
| Yes | 5 | 16 | |
| Lymph node infiltrate (N = 99) | |||
| Absent | 4 | 2 | 0.39 |
| Present | 39 | 54 | |
| Primary tumor | |||
| pT1 and pT2 | 18 | 21 | 0.83 |
| pT3 and pT4 | 26 | 35 | |
| Staging | |||
| I–II | 38 | 51 | 0.52 |
| III–IV | 6 | 5 | |
| Lymph node metastasis (N = 44) | |||
| Absent | 6 | 10 | 1 |
| Present | 11 | 17 | |
| Extra node extension (N = 43) | |||
| Absent | 7 | 10 | 0.76 |
| Present | 12 | 14 | |
| Koilocytosis | |||
| Absent | 1 | 12 | 0.10 |
| Present | 28 | 59 | |
| Invasion pattern (N = 97) | |||
| Expansive | 23 | 53 | 0.14 |
| Infiltrative | 3 | 18 | |
| Histological subtype (N = 98) | |||
| Basaloid | 5 | 1 | 0.001 |
| Warty | 14 | 15 | |
| Usual | 3 | 32 | |
| Warty-basaloid | 4 | 5 | |
| Mixed | 2 | 17 | |
| Others | 1 | 1 | |