Table 3.

What do patients need to know about non-invasive prenatal testing in order to give informed consent for the test

	n (%)
NIPT (in general)
NIPT is a screening test and not diagnostic	431 (90.7)
What conditions can be detected with NIPT	427 (89.9)
How much NIPT costs	425 (89.5)
NIPT analyzes cell-free fetal DNA in maternal blood	355 (74.7)
NIPT could detect chromosomal changes of unknown significance	252 (53.1)
Accuracy of NIPT for each genetic condition it is screening for	238 (50.1)
The clinical presentation and prognosis of the genetic conditions NIPT can screen for	229 (48.2)
NIPT results
That results may need to be confirmed with diagnostic testing	418 (88.0)
What a ‘positive’ or ‘negative’ result means	415 (87.4)
How long it takes to receive the NIPT results	376 (79.2)
How the results will be provided to the patient	369 (77.7)
What options are available following a high-probability NIPT result	352 (74.1)
What diagnostic testing involves and the associated risks	319 (67.2)
Limitations of NIPT
That NIPT cannot detect all genetic conditions	419 (88.2)
Possibility of a false positive or false negative NIPT result	409 (86.1)
Possibility of receiving incomplete or no results	403 (84.8)
NIPT cannot detect all other possible causes of a condition or disability	353 (74.3)
Possibility of incidental findings	271 (57.1)
Sex of the baby cannot be withheld if an sex chromosome aneuploidy is suspected	229 (48.2)
Reasons that someone may receive incomplete or no results	207 (43.6)
NIPT results could be affected by placental mosaicism	196 (41.3)
The type of incidental findings that are possible	117 (24.6)
Post-test management of sample and test results
How data from results will be managed and/or used in the future	268 (56.4)
How the blood sample will be managed and/or used in the future	159 (33.5)
How long data from results will be stored	127 (26.7)
How long the blood sample will be stored	110 (23.2)