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Cytotoxic effect of GNR-PEG-Ang2/D1 on cells that constitute the BBB at three different concentrations. A-C, cytotoxic effect of the nanosystem on each cell line, evaluated separately. D and E, GNR-PEG-Ang2/D1 analyzed on the endothelial barrier in the BBB-on-a-chip. GNR-CTAB was used as a control. Adapted with permission from Ref. [292]. Copyright, 2023 Springer Nature
