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. 2024 May 13;22:248. doi: 10.1186/s12951-024-02526-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — A Quantification of total Tau concentration in serum samples of control and GNP-PEG-treated tau P301L mice using an ELISA assay after 30 days of treatment. B Quantification of integrated optical densities (IOD) values in control (n = 6) and treated groups (n = 6) for paired helical filament-positive cells using Image-Pro Plus analysis. C Novel object recognition test for the examination of learning and memory, in which the mice exhibited altered velocity. Adapted with permission from Ref. [194].

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