Table 5. Demographics and Clinical Characteristics for Pancreatic Cancer by Histology.
| Pancreas | All | Adenocarcinoma | Squamous | Adenosquamous | P value |
|---|---|---|---|---|---|
| N (%) | 250,034 (100.0) | 149,409 (59.8) | 530 (0.2) | 1,273 (0.5) | |
| Age (years) (%) | |||||
| 0 - 14 | 94 (< 1) | 1 (< 1) | 0 (0.0) | 0 (0.0) | 0.66 |
| 15 - 29 | 696 (0.3) | 94 (0.1) | 0 (0.0) | 0 (0.0) | |
| 30 - 49 | 14,416 (5.8) | 7,915 (5.3) | 33 (6.2) | 70 (5.5) | |
| 50 - 69 | 105,829 (42.3) | 68,078 (45.6) | 220 (41.5) | 564 (44.3) | |
| 70 - 89 | 128,999 (51.6) | 73,321 (49.1) | 277 (52.3) | 639 (50.2) | |
| Mean (SD) | 68.9 (11.8) | 68.4 (11.1) | 68.6 (11.5) | 68.4 (10.5) | 0.91 |
| Median | 70 | 69 | 70 | 70 | |
| Sex (%) | |||||
| Male | 128,060 (51.2) | 77,717 (52.0) | 282 (53.2) | 671 (52.7) | 0.76 |
| Female | 121,974 (48.8) | 71,692 (48.0) | 248 (46.8) | 602 (47.3) | |
| Race (%) | |||||
| White | 203,422 (81.4) | 121,475 (81.3) | 403 (76.0) | 1,027 (80.7) | 0.032 |
| Black | 26,897 (10.8) | 16,531 (11.1) | 74 (14.0) | 140 (11.0) | |
| Other | 19,715 (7.9) | 11,403 (7.6) | 53 (10.0) | 106 (8.3) | |
| Detection stage (%) | |||||
| Localized | 26,418 (10.6) | 11,737 (7.9) | 30 (5.7) | 112 (8.8) | < 0.001 |
| Regional | 68,912 (27.6) | 43,426 (29.1) | 133 (25.1) | 488 (38.3) | |
| Distant | 129,160 (51.7) | 86,543 (57.9) | 329 (62.1) | 632 (49.6) | |
| Unstaged | 25,544 (10.2) | 7,703 (5.2) | 38 (7.2) | 41 (3.2) | |
| Grade differentiation (%) | |||||
| Well | 14,289 (5.7) | 5,895 (3.9) | 14 (2.6) | 6 (0.5) | < 0.001 |
| Moderate | 31,406 (12.6) | 19,930 (13.3) | 42 (7.9) | 148 (11.6) | |
| Poor | 34,609 (13.8) | 22,413 (15.0) | 163 (30.8) | 429 (33.7) | |
| Unknown | 169,730 (67.9) | 101,171 (67.7) | 311 (58.7) | 690 (54.2) | |
| Surgery (%) | |||||
| Yes | 44,939 (18.0) | 19,802 (13.3) | 45 (8.5) | 461 (36.2) | < 0.001 |
| No | 205,095 (82.0) | 129,607 (86.7) | 485 (91.5) | 812 (63.8) | |
| Chemotherapy (%) | |||||
| Yes | 105,126 (42.0) | 75,021 (50.2) | 219 (41.3) | 703 (55.2) | < 0.001 |
| No | 144,908 (58.0) | 74,388 (49.2) | 311 (58.7) | 570 (44.8) | |
| Radiotherapy (%) | |||||
| Yes | 34,417 (13.8) | 24,021 (16.1) | 86 (16.2) | 207 (16.3) | 0.98 |
| No | 215,617 (86.2) | 125,388 (83.9) | 444 (83.8) | 1,066 (83.7) | |
| Incidence rate (95% CI) | - | ||||
| All | 123.6 (123.1 - 124.1) | 71.2 (70.9 - 71.7) | 0.23 (0.21 - 0.25) | 0.63 (0.59 - 0.66) | |
| Male | 140.3 (139.4 - 141.1) | 82.1 (81.5 - 82.8) | 0.28 (0.24 - 0.32) | 0.73 (0.67 - 0.79) | |
| Female | 109.7 (109.1 - 110.4) | 62.3 (61.8 - 62.8) | 0.19 (0.16 - 0.22) | 0.54 (0.50 - 0.59) | |
| CSS (95% CI) | - | ||||
| 1-year | 32.0 (31.8 - 32.2) | 28.0 (27.7 - 28.3) | 17.7 (13.5 - 22.4) | 27.7 (24.7 - 30.8) | |
| 2-year | 17.6 (17.4 - 17.8) | 11.5 (11.3 - 11.7) | 7.2 (4.5 - 10.7) | 13.4 (11.1 - 16.0) | |
| 5-year | 9.6 (9.4 - 9.7) | 3.9 (3.8 - 4.0) | 3.3 (1.6 - 6.2) | 6.7 (4.9 - 8.8) | |
| 10-year | 7.3 (7.1 - 7.4) | 2.6 (2.5 - 2.7) | 3.3 (1.6 - 6.2) | 4.7 (3.0 - 7.0) | |
| Median (months) | 5.9 | 5.7 | 3.7 | 5.9 | |
| RS (95% CI) | - | ||||
| 1-year | 30.3 (30.0 - 30.5) | 26.6 (26.3 - 26.9) | 16.4 (12.5 - 20.9) | 26.5 (23.6 - 29.5) | |
| 2-year | 16.1 (16.0 - 16.3) | 10.5 (10.4 - 10.7) | 6.4 (4.0 - 9.7) | 12.4 (10.2 - 14.8) | |
| 5-year | 8.1 (7.9 - 8.2) | 3.3 (3.1 - 3.4) | 2.7 (1.2 - 5.2) | 5.7 (4.1 - 7.6) | |
| 10-year | 5.1 (5.0 - 5.3) | 1.7 (1.6 - 1.9) | 2.7 (1.2 - 5.2) | 3.2 (1.9 - 5.1) | |
| Median (months) | 5.4 | 5.4 | 3.6 | 5.7 |
P < 0.05 for all comparisons between adenocarcinoma, squamous cell carcinoma and adenosquamous cell carcinoma comparisons. Incidence rates were expressed per 100,000. CSS: cause-specific survival; RS: relative survival; CI: confidence interval; SD: standard deviation.