Extended Data Figure 6. Representative mass spectrometry of tau from the sarkosyl-insoluble fractions of cases with mutation R406W in MAPT.

MALDI mass spectra of parietal cortex from case 1 (a) and frontal cortex from case 2 (b). Wild-type (R406) and mutant (W406) peptides were detected in parietal cortex from case 1. Only mutant peptides (W406) were detected in frontal cortex from case 2. Similarly, only mutant peptides were detected in temporal cortex and hippocampus from case 1, as well as in temporal cortex, parietal cortex and hippocampus from case 2.