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a, Cryo-EM density and atomic model of paired helical filament (PHF) from the frontal cortex of case 2. Two identical protofilaments extend from G273/304-E380.
b, Overlay of PHFs extracted from the frontal cortex of case 2 (blue) and the frontal cortex of a case of sporadic AD (black). The rmsd between Cα atoms of the two structures is 0.78 Å.
