Extended Data Figure 3. R406W mutation in MAPT: Immunohistochemical localisation of tau in temporal cortex, parietal cortex and hippocampus of case 1.

a,c,e, Tau-immunopositive nerve cell bodies (arrows) and neuropil threads (arrowheads) are shown in temporal cortex; b,d, parietal cortex; f, hippocampus. c,d,e,f, Labelled astrocytes (double arrowheads). Panel (d) shows plaques composed of numerous threads, corresponding probably to the processes of neurons and astrocytes. Antibodies: AT8 (a,b,d,f); RD4 (c); RD3 (e). Scale bar, 25 μm.