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(a) Surface view of ZIKV NS3Hel fragment screening results in two orientations. Surface is colored in grey, and fragments are depicted as sticks with yellow carbons. Selected cluster of fragments are marked with orange (1), blue (2) and green (3) boxes. (b) Overlaid structures of 111 PBDs containing superfamily 2 helicases from Flaviviridae family. Small molecules are depicted as sticks.
