Figure 3. Temporal shifts in transcriptomes.

A. Heatmaps showing degree of similarity among scRNA-seq transcriptomes (1:1 orthologues only) for four different embryonic cell lineages. Assignment of cells to lineages is based on optimal transport (see Methods). Red boxes indicate the most similar time point of He for each time point of Lv. B. Line plots showing developmental time of best matches among transcriptomes in panel A. Note the overall delay in He, with most points above the line defined by a slope of 1. C. Line plot showing developmental time of morphogenetic events. Again, there is an overall delay in He.