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[Preprint]. 2024 Jul 21:2024.04.30.591674. Originally published 2024 May 1. [Version 2] doi: 10.1101/2024.04.30.591674

Figure 4. Pair-housed C57Bl/6J mice do not show changes in adulthood EtOH consumption in an IA2BC model.

Figure 4.

(A) Experimental schematic. (B-E) Neither EtOH preference nor intake was altered as a function of sex or adolescent EtOH exposure during the first adulthood IA2BC session on PND 90. (F-I) Female mice consumed significantly more EtOH during the final adulthood IA2BC session on PND 120, but this was not modulated by adolescent EtOH exposure. (J-K) Female mice consumed more EtOH across all 15 adulthood drinking sessions. (L-M) EtOH intake and preference across all 15 IA2BC sessions, split by sex. Significant predictors identified by GLME are indicated on each graph. Trendlines in D-E, H-I, K represent the line of best fit for each sex. B-K: Each value represents one cage with two mice. ** = p < .01, *** = p < .001.