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[Preprint]. 2024 May 30:2024.05.05.592554. [Version 4] doi: 10.1101/2024.05.05.592554

PMC11092766.3; 2024 May 8
PMC11092766.4; 2024 May 30
PMC11092766.5; 2024 Nov 22

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Figure 2. — Genetic inhibition of adrb1 signaling could rescue CCM in ccm2 CRISPR zebrafish. (A through F) Representative light sheet microscopy scanning pictures of brains from ccm2 CRISPR adult zebrafish of wild type (A through C) and of adrb1^−/− (D through F). Brains from ccm2 CRISPR on wild type background show lesions indicated by arrows (A through C), while brains from ccm2 CRISPR on adrb1^−/− do not show lesions (D through F). Scale bar: 1mm. (G) Statistical analysis of lesion volume by unpaired two-tailed t test. P=0.0005.