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[Preprint]. 2024 Nov 22:2024.05.05.592554. [Version 5] doi: 10.1101/2024.05.05.592554

PMC11092766.3; 2024 May 8
PMC11092766.4; 2024 May 30
PMC11092766.5; 2024 Nov 22

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Figure 2. — Genetic inhibition of adrb1 signaling could rescue CCM in ccm2 CRISPR zebrafish. (A through F) Representative light sheet microscopy scanning pictures of brains from ccm2 CRISPR adult zebrafish of adrb1^+/+ (A through C) and of adrb1^−/− (D through F) on Tg(fli1:EGFP) background. Brains from ccm2 CRISPR on wild type background show lesions indicated by arrows (A through C), while brains from ccm2 CRISPR on adrb1^−/− do not show lesions (D through F). Scale bar: 1mm. (G) Statistical analysis of total lesion volume by unpaired two-tailed t test. P=0.0005. 12 adrb1^−/− brains and 13 adrb1^+/+ brains were analyzed.