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. Author manuscript; available in PMC: 2024 May 14.
Published in final edited form as: Leukemia. 2023 Dec 20;38(2):416–419. doi: 10.1038/s41375-023-02111-8

Fig. 2. Aims of the ReCord study, 2021-ongoing.

Fig. 2

Aim 1: Enroll childhood leukemia patients with banked cord blood, then sequence leukemia specimens to determine the driving molecular lesions in each patient, followed by backtracking in cord blood using patient-specific droplet digital PCR (ddPCR) assays to determine which leukemia subtypes arise prenatally and their clonal frequency across cord blood cell compartments. Aim 2: Investigate the cell-of-origin of leukemia-initiating lesions and transcriptomic changes from pre-leukemia to overt leukemia, across childhood leukemia subtypes, at the single-cell level using TARGET-Seq in paired cord blood and diagnostic leukemia samples. Aim 3: To determine whether the presence and frequency of pre-leukemic clones correlate with leukemia risk factors, including demographic, pre/perinatal, and genomic risk factors for ALL/AML. Created with BioRender.com.