TABLE 5.

Comparison of the individual and combined AUCs for ITIH5 and CA199 in patients with CCA and iCCA versus HCC, benign hepatobiliary diseases, chronic hepatitis B, and healthy individuals.

	ITIH5 versus CA19‐9	ITIH5 versus ITIH5 + CA19‐9	CA19‐9 versus ITIH5 + CA19‐9
CCA versus controls
CCA‐HCC	0.437	0.023*	0.007**
CCA‐Benign	0.039*	0.212	0.041*
CCA‐CHB	0.958	0.007**	0.008**
CCA‐Healthy	0.247	0.006**	0.034*
CCA‐NCCA	0.396	0.284	0.073
iCCA versus controls
iCCA‐HCC	0.057	0.314	0.009**
iCCA‐Benign	0.007**	0.283	0.012*
iCCA‐CHB	0.158	0.102	0.039*
iCCA‐Healthy	0.467	0.077	0.073
iCCA‐NCCA	0.053	0.781	0.029*

Abbreviations: AUC, area under the receiver‐operating characteristic curve; Benign, benign hepatobiliary diseases; CCA, cholangiocarcinoma; CHB, chronic hepatitis B; HCC, hepatocellular carcinoma; Healthy, healthy individuals; iCCA, intrahepatic cholangiocarcinoma; NCCA, the total patients without CCA.

^* p < 0.05.

^** p < 0.01.