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. 2024 Mar 13;115(5):1388–1404. doi: 10.1111/cas.16128

FIGURE 3.

FIGURE 3

Human leukocyte antigen‐II (HLA‐II) molecules are related to the expression of interleukin‐10 (IL‐10) in glioblastoma (GBM). (A) Based on the RT‐PCR results of 21 pairs of fresh tumor tissues, the expression of HLA‐DP was upregulated in 13 cases of GBM, and HLA‐DQ was upregulated in 14 cases of GBM. (B, C) GBM cases were divided into HLA‐II upregulation and HLA‐II downregulation groups. The expression of IL‐10, transforming growth factor‐β (TGF‐β), and prostaglandin E2 (PGE2) in fresh GBM samples was compared between those two groups (p < 0.05). (D) Representative immunohistochemical (IHC) images show the expression of IL‐10 in paraffin‐embedded GBM specimens. (E) Expression of IL‐10 was compared between GBM and control specimens (p < 0.001). (F) Survival outcomes of patients were shown according to the expression of IL‐10 in paraffin GBM specimens. (G) Representative IHC images indicate the expression of HLA‐DP, HLA‐DQ, and IL‐10 in paraffin GBM specimens. (H, I) Spearman's correlation analysis indicates the relationship between the expression of HLA‐II and IL‐10 in paraffin GBM specimens (n = 51). (J, K) Survival outcomes of patients were shown according to both HLA‐II and IL‐10 expression in paraffin GBM specimens, HLA‐IILowIL‐10Low versus HLA‐IIHighIL‐10High (n = 46). N, Normal control brain; T, Tumor.