TABLE 2.

PDAC Metallome. (A) Levels of metals in serum from PDAC and healthy controls. (B) Levels of metals in tumor and adjacent normal pancreas tissue from PDAC patients.

(A) Serum
	PDAC			Healthy controls			p‐value*
	Mean	SD	Median	Mean	SD	Median
24Mg (mM)	0.715	0.126	0.720	0.815	0.129	0.820	<0.001
39K (mM)	4.167	2.134	4.000	4.317	0.664	4.350	0.001
44Ca (mM)	2.106	0.324	2.135	2.334	0.324	2.300	<0.001
57Fe (μM)	14.790	9.393	12.750	21.540	7.062	20.300	<0.001
63Cu (μM)	16.770	4.779	16.200	16.310	3.486	16.000	0.690
68Zn (μM)	9.875	2.279	9.800	10.980	2.626	10.900	0.003
78Se (μM)	0.993	0.397	0.925	1.424	0.327	1.365	<0.001
55Mn (nM)	22.460	14.820	17.000	20.820	11.700	18.500	0.694
59Co (nM)	4.754	7.786	2.000	4.080	8.595	3.000	0.443
95Mo (nM)	14.990	7.609	13.500	12.250	7.730	11.000	<0.001
63Cu:57Fe	1.405	0.778	1.229	0.844	0.379	0.794	<0.001
63Cu:68Zn	1.759	0.608	1.691	1.533	0.367	1.497	0.002
75As (nM)	25.320	70.120	8.500	19.030	22.550	11.000	0.022
202Hg (nM)	3.681	3.052	3.000	5.318	3.168	5.000	<0.001
Pb (nM)	0.812	1.359	0.000	0.421	0.656	0.000	0.035

(B) Tissue
(μg/g)	Tumor tissue			Adjacent normal pancreas			p‐value*
	Mean	SD	Median	Mean	SD	Median
24Mg	417.200	147.900	424.100	410.900	231.700	452.500	0.6491
39K	6962.000	3371.000	6743.000	6821.000	4238.000	7218.000	0.9154
44Ca	545.900	208.000	523.200	432.400	257.500	370.700	<0.0001
57Fe	185.700	197.600	131.800	162.200	152.900	112.400	0.1550
63Cu	5.728	4.852	4.870	6.471	10.510	4.510	0.5484
68Zn	60.830	27.630	56.950	87.540	56.750	86.210	0.0026
78Se	0.982	0.391	1.004	0.715	0.474	0.777	<0.0001
55Mn	1.242	1.234	0.890	2.929	2.262	2.510	<0.0001
59Co	0.034	0.029	0.027	0.034	0.024	0.031	0.4350
95Mo	0.105	0.108	0.088	0.171	0.235	0.137	0.0005
63Cu:57Fe	0.044	0.041	0.035	0.052	0.083	0.038	0.5251
63Cu:68Zn	0.105	0.111	0.084	0.138	0.405	0.055	0.0182
75As	0.075	0.078	0.048	0.060	0.067	0.037	0.1645
202Hg	0.046	0.052	0.035	0.039	0.047	0.022	0.4870
Pb	0.065	0.094	0.042	0.255	0.684	0.104	<0.0001

^*Mann–Whitney U‐test.