TABLE 3.

Receiver operator curve analysis for: (A) serum levels of metals; and (B) tissue levels of metals.

(A) Serum (PDAC vs. healthy controls)
	AUROC	p‐value	Optimal cut‐off	Sensitivity (%)	Specificity (%)
24Mg (mM)	0.715	<0.001	<0.765	67.390	67.050
39K (mM)	0.651	0.001	<4.250	61.590	57.950
44Ca (mM)	0.702	<0.001	<2.225	65.940	65.910
57Fe (μM)	0.789	<0.001	<17.250	71.740	71.590
63Cu (μM)	0.516	0.689	>16.050	52.900	51.140
68Zn (μM)	0.615	0.004	<10.250	56.520	57.950
78Se (μM)	0.874	0.001	<1.215	85.510	78.410
55Mn (nM)	0.516	0.693	<17.500	53.620	56.820
59Co (nM)	0.529	0.456	<2.500	57.970	51.140
95Mo (nM)	0.659	0.001	>12.500	57.250	67.050
63Cu:57Fe	0.778	<0.001	>0.927	73.190	73.860
63Cu:68Zn	0.623	0.002	>1.572	61.590	62.500
75As (nM)	0.590	0.023	<10.500	60.140	54.550
202Hg (nM)	0.673	<0.001	<3.500	57.970	70.450
Pb (nM)	0.573	0.063	>0.500	47.830	63.640

(B) Tissue (tumor vs. adjacent normal pancreas)
(μg/g)	AUROC	p‐value	Optimal cut‐off	Sensitivity (%)	Specificity (%)
24Mg	0.5205	0.6477	<433.6	53.01	51.81
39K	0.5049	0.9138	>6299	57.83	43.37
44Ca	0.6908	<0.0001	>462.9	68.66	63.86
57Fe	0.5640	0.1544	>123.9	53.63	53.63
63Cu	0.5271	0.5470	>4.515	54.22	50.60
68Zn	0.6346	0.0027	<64.21	62.65	62.65
78Se	0.6978	<0.0001	>8970	65.06	62.65
55Mn	0.7023	<0.0001	<1.320	73.49	69.88
59Co	0.5352	0.4335	<0.0295	59.04	57.83
95Mo	0.6560	0.0005	<0.1065	63.86	60.24
63Cu:57Fe	0.5287	0.5236	<0.03673	53.01	53.01
63Cu:68Zn	0.6060	0.0184	>0.07801	60.24	59.04
75As	0.5625	0.1644	>0.04125	59.04	54.22
202Hg	0.5311	0.4885	>0.02650	59.04	61.45
Pb	0.7309	<0.0001	<0.05873	68.67	68.67