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. 2024 Mar 3;115(5):1706–1717. doi: 10.1111/cas.16127

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© 2024 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Locations and genes undergoing hydroxymethylation during malignant progression. (A, B) Distribution enrichment analysis of common hydroxymethylated CpGs (CoHMC) 3120 probes with CpG island region and gene‐centric region systems (Fisher's exact test). Total probe distribution was used as reference distribution data. (C, D) Kyoto Encyclopedia of Genes and Genomes pathway analysis of CoHMC‐related all genes and transcription factor‐coding genes. Cancer‐related pathways are represented by filled dots and annotated.