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. 2024 Mar 3;115(5):1706–1717. doi: 10.1111/cas.16127

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© 2024 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Gene Set Enrichment Analysis (GSEA) of high‐grade gliomas (HGG) compared with low‐grade glioma (LGG). (A) GSEA analysis of oncogenic signatures in the current cases. HGG (after malignant progression [MP]) compared with LGG (before MP) suggests upregulation of oncogenic signature gene sets involved in cell‐cycle processes (e.g., RB_DN.V1_UP, EIF4E_UP, MYC_UP.V1_UP) during MP. (B) Balloon chart displaying GSEA enrichment score and the significance of HGG compared with LGG. Balloon size represents −log10(p‐value), with the value written inside each balloon. Gene sets are plotted in order of normalized enrichment score.