Sequence and chromosomal location of the TGEV subclones. The consensus amino acid changes that differ from the published sequence are shown in each of the final clones used to assemble a full-length TGEV construct (17). Each of these changes in the TGEV sequence has also been noted by Almazan et al. (3) at all indicated positions except those denoted by an asterisk. The relative locations of the different TGEV motifs were taken from Eleouet et al. (17). Abbreviations: PL, papain-like protease; GFL, growth factor-like domain; Pol, polymerase motif; MIB, metal-binding motif; Hel, helicase motif; VD, variable domain; CD, conserved domain; ↑, intergenic starts.